‘De novo Structural Modeling and Conserved Epitopes Prediction of Chikungun

日期 : Jun 2017 - 现在

In recent studies novel antigenic epitopes of some essential and vital proteins are revealed that can victoriously elicit response of immune system therefore becoming great peptide vaccines targets and protecting host from virus attack. So, the current research was organized to conclude or predict antigenic epitopes of structural polyprotein of CHIK V. We carry out sequence, structure, and conservation analysis as well as homology modeling of structural polyprotein of CHIK V. This research discloses T and B cell epitopes which are antigenic and conserved between 17 different countries. These epitopes are capable to induce a particular immunologic response.We rely on that, few of the antigenic epitopes estimatedand investigated in this work might present a preliminary set of peptides for future vaccine developmentagainst CHIKV for weeding out of persistent infections.